HealthShare Exchange is the health information organization launched in 2009 in the Southeastern Pennsylvania and the greater Philadelphia region. HSX is a unique, membership-dues-supported nonprofit formed by the Delaware Valley’s hospitals/health systems and healthcare insurers. It makes electronic patient-care information available securely throughout the area’s medical system, linking data across hospital systems and healthcare insurers, medical practices, and other providers. It takes advantage of medical center and health plan data, making recent medical history and alerts to care events accessible and interchangeable at the point of care, within the electronic medical record (EMR) systems and other workflow of those who deliver care, and to those who manage care. This exchange seeks to help healthcare organizations improve patient outcomes and manage and lower healthcare costs. The HSX platform and its growing clinical data repository also serve as powerful resource for innovators, researchers, and public- and population-health entities.